Correlation between Advanced Oxidation Protein Products (AOPP) and Antioxidant status in Type 2 diabetics in Southern Asian Region

Incidence & prevalence of type 2 DM is increasing in worldwide but greatest prevalence in Asian population as also its chronic complications. Oxidative stress is believed to be a common pathogenic factor for these grave consequences. Advanced oxidation protein product (AOPP) is a marker of protein damage whereas total oxidant status(TOS) reflects the severity of oxidative stress. Different results were found by different authors about correlations between these markers and antioxidant status. It was a cross sectional study. 50 patients of clinically diagnosed type 2 DM & 47 age and sex matched controls were selected for the study, according to inclusion and exclusion criteria. We analysed HbA1C, AOPP, TOS and Trolox Equivalent Antioxidant Capacity (TEAC) in diabetes patients and compared them with controls. (HbA1C was estimated by boronate affinity chromatography, and others were estimated spectrophotometrically). We also tried to find out any correlation between oxidants (AOPP and TOS) and antioxidant ( TEAC). Significant increase in mean HbA1C, AOPP (p<0.0001) and increase in mean TOS level (p<0.184) were found in diabetes patients in comparison to controls. We also observed significant decrease in mean TEAC levels (p<0.0001). Significant negative correlations were observed between TEAC& AOPP (r=-0.99,p<0.0001,y=1.607-0.004x) AOPP accumulation is correlated with increased antioxidant consumption in type 2 diabetes. Estimation of AOPP is very much beneficial for prediction of chronic and grave complications of type 2 diabetes.